Hit the jump to hear more about microchip drug delivery.
The chip is one-fiftieth of an an inch thick and measures about half and inch long by a fifth of an inch wide. It contains 10 reservoirs, each holding 600 nanoliters of highly concentrated drug. The sides are covered in a metallic membrane made of a composite of titanium and platinum, wired to electronics that provide a path for a current. To deliver the drug, the membrane is melted, releasing the necessary dose. The chip can be programmed to release drugs on a timed schedule, or manually by an operator using a computer. Teriparatide was an excellent candidate for this delivery approach, as it requires daily injections, and let's face it, daily administration of anything can instill compliance issues. The implantable chip will hopefully elimate these types of problems.
In the study, seven osteoporotic postmenopausal patients between the ages of 65 and 70 received the microchip-based implant. The primary objective of the clinical trial was to assess the pharmacokinetics of the released drug teriparatide from the implanted devices. Safety measures included evaluation of the biological response to the implant and monitoring indicators of toxicity. Secondary objectives were to assess the bioactivity of the drug and to evaluate the reliability and reproducibility of releasing the drug from the device.
The results thus far seem promising. Blood tests showed that the drugs dispensed by the microchip was as effective as ordinary injections in increasing bone mass and bone mineral density.
Pretty cool stuff, I suppose. I mean, if people weren't so lazy, this probably wouldn't be necessary. However, I could see the benefit for some drugs, that maybe are a little more unconfortable to self-administer.